IMMUNOBIOLOGY Broad influenza-specific CD8 T-cell responses in humanized mice vaccinated with influenza virus vaccines
نویسندگان
چکیده
1Baylor National Institute of Allergy and Infectious Diseases (NIAID) Cooperative Center for Translational Research on Human Immunology, INSERM U899, Baylor Institute for Immunology Research, Dallas, TX; 2Baylor University, Waco, TX; 3University of Texas Southwestern, Dallas, TX; and 4Department of Microbiology, Emerging Pathogens Institute, and NIAID Center for Investigating Virus Immunity and Antagonism, Mount Sinai School of Medicine, New York, NY
منابع مشابه
Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines.
The development of novel human vaccines would be greatly facilitated by the development of in vivo models that permit preclinical analysis of human immune responses. Here, we show that nonobese diabetic severe combined immunodeficiency (NOD/SCID) beta(2) microglobulin(-/-) mice, engrafted with human CD34+ hematopoietic progenitors and further reconstituted with T cells, can mount specific immun...
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